Crystallographic Fragment Screening
Crystallographic Fragment Screening (CFS) is a technique used in the early stages of drug discovery to identify potential drug candidates. In this method, protein crystals are co-incubated with a library of small molecule fragments (typically ranging from 110-250 Da), where these small molecules represent potential drug fragments, then by analyzing the X-ray diffraction data from these crystals, it is possible to observe the specific binding of these fragments in the electron density map. CFS is a powerful technique that combines structural biology and medicinal chemistry approaches, with broad application prospects in drug discovery and development.
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