Family :

Virus Protein

Catalog No. :


Protein :


UniProt :


Organism :

Bat coronavirus HKU4

Expression system :

E. coli

Tag :


Sequence :


Inquiry :

Symbol/Gene Name:  1a

Alias:  Replicase polyprotein 1a,pp1a,ORF1a polyprotein

Uniprot: P0C6T4

Background: The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating /deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF-3 (By similarity).

Construct: 6His-TEV-(G)-HKU4-NSP5(S3292-Q3597)

Expression Host: E. coli

Purity: 90%

Formulation: 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol 

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.


< 0.01 EU per μg of the protein


Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.