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Membrane Proteins

ABC Transporters

  • ABCB10

    2.9 Å
    33603
    Q9NRK6

  • ABCC4，MRP4

    2.5 Å
    37735
    O15439

  • ABCG2

    2.7Å
    37766
    Q9UNQ0

ABC transporters are a class of transmembrane proteins present in all eukaryotes and prokaryotes. They harness energy from ATP hydrolysis to transport substances across membranes, facilitating the exchange of materials inside and outside cells, making them critical targets for drug development and therapies for genetic disorders 【1-2】

Widely distributed in the intestines, blood-brain barrier, and placenta, ABC transporters mediate the transport of phospholipids, lipophilic drugs, cholesterol, and other small molecules. They play vital roles in normal physiological transport processes and in the elimination of exogenous toxic substances and metabolic waste. Dysfunctions are associated with diseases including adrenoleukodystrophy, cystic fibrosis, retinal degeneration, hypercholesterolemia, and cholestasis 【3】 .

ABC transporters can transport a diverse range of substances, including drugs and antibiotics. Modulating the activity or expression levels of ABC transporters may alter drug distribution and efficacy in the body, offering new strategies for drug design and optimization 【4-5】 .

References

【1】Rees D C, Johnson E, Lewinson O. ABC transporters: the power to change[J]. Nature reviews Molecular cell biology, 2009, 10(3): 218-227.
【2】Leonard G D, Fojo T, Bates S E. The role of ABC transporters in clinical practice[J]. The oncologist, 2003, 8(5): 411-424.
【3】Ter Beek J, Guskov A, Slotboom D J. Structural diversity of ABC transporters[J]. Journal of General Physiology, 2014, 143(4): 419-435.
【4】Linton K J. Structure and function of ABC transporters[J]. Physiology, 2007, 22(2): 122-130.
【5】Thomas C, Tampé R. Structural and mechanistic principles of ABC transporters[J]. Annual review of biochemistry, 2020, 89: 605-636.

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